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Paw Paw Offers Hope for Cancer

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Dr. McLaughlin

Dr. McLaughlin

The pawpaw tree is indigenous to several areas of North America. 

Some have theorized that it receives its name due to its similar appearance to the papaya fruit; however, the two fruits are totally unrelated.  Pawpaw is of the scientific family Annonaceae, which includes several unusual tropical fruits. 

There are about eight different species of pawpaw; however it is the species Asimina triloba that was used by Dr. Jerry McLaughlin in his research, and it is only this species that contains the special annonaceous acetogenins that have been shown to so powerful in fighting insects, cancer cells, parasites, lice, and other attackers.  The pawpaw is a cousin to the fruit known as graviola, but research has proven that although graviola has some similar natural chemical compounds, it is not as desirable or as powerful as Asimina triloba for medical use.  Unfortunately, however, some opportunistic companies will market graviola as an equal.   It is not.

 The trees themselves are not large as far as trees go.  Some are about the size of large shrubs, although many grow as high as 25 feet, and sometimes a little more.  The fruit itself is about the size of a large human fist–usually 3-6 inches long– and is considered by many to be very tasty.  It is often compared to a combination of some sort of banana, coconut, mango, and possibly others. One reason that it is not available too often in retail settings is that it spoils quickly after it is harvested.  However, those who are fortunate enough to find a ripe fruit on a tree and eat it fresh are usually rewarded with a very pleasant tasting experience.

The fruit is also highly nutritious–very rich in proteins, good fats, and complex carbohydrates.  It is normally ripe in the fall, usually in September.  The explorers Meriwether Lewis and William Clark were known to have survived on pawpaw for about a month during their famous exploratory trip.

As a child, Jerry McLaughlin ate the fruit and felt that there must be something biologically active.  As a Professor of Pharmacognosy at Purdue University, he spent over 20 years studying this fruit.  He discovered the presence of a natural chemical in the tree called an acetogenin.  An acetogenin is a long-chained, fatty acid substance with some very unique properties.  Over 400 of these compounds have been found in nature, many of them by researchers working with Dr. McLaughlin at Purdue University.  In other parts of the world, researchers have been looking for acetogenins in other fruits of the same family.  However, the double-ringed features of the powerful acetogenins in the Asimina triloba have not been found to date in those other fruits.

Interestingly enough, the acetogenins that are so powerful are not as plentiful in the fruit as in the twigs of the tree.  Also, Dr. McLaughlin found that the acetogenin levels peaked in the twigs during the month of May.  Just as important, he found the levels of acetogenins vary even by location of the Asimina triloba trees.  Some groves produce higher levels than others.  Thus, if someone is considering using pawpaw as a treatment, it is not only important to ensure that the product is from the Asimina triloba species of pawpaw, but also that the product is standardized–in other words, the manufacturer uses an extraction process for the acetogenins and ensures that a guaranteed set amount (standardized amount) of acetogenins is actually in the product.  At this point, only one manufacturer in the world has the capability of accomplishing this, partially because Dr. McLaughlin has licensed his patent and methodology to them.

Steven Horne of Tree of Light Publishing put out a handout about the only standardized pawpaw product available.  Good quick source of information.  Published in 2003, some of the information about the antioxidants is a little outdated since recent tests by the Josephine Ford Cancer Center in Detroit indicate that using antioxidants with pawpaw does not interfere with the pawpaw action.

Look What’s Hidden in the Paw Paw Tree Fruit

During World War II, when bananas were scarce, Jerry L. McLaughlin’s dad gave him some “Indiana bananas” — the custard-like fruit of Asimina triloba, better known as the pawpaw tree. Though only about 4 years old at the time, McLaughlin recalls, “I threw up and never forgot them.”

A pharmacognosist at Purdue University in West Lafayette, Ind., McLaughlin now searches for plants possessing natural medicinal properties. Based on his unforgettable encounter with the Indiana banana, he focused a few years ago on the pawpaw. After all, he notes, “parmacology is simply toxicology at a lower dose.” The result: He reports finding a family of biologically active compounds — acetogenins — “that’s very good against cancer, and also terrific at killing insects.”

A crude extract of pawpaw twigs killed brine shrimp at a concentration of just 0.04 parts per million (ppm)–well below the 70 ppm concentration of strychnine needed to elicit the same effect. One novel acetogenin his team isolated from the pawpaw extract — asimicin — also proved lethal to blowfly larvae, two-spotted spider mites, Mexican bean beetles, mosquito larvae, melon aphids, striped cucumber beetles and a nematode. McLaughlin expects that natural asimicin-based pesticides, for which he holds a patent, may be marketed within four or five years.

McLaughlin also subjected brine shrimp to extracts from the pawpaw’s relatives. He hit a lode with Annona bullata, a Cuban native closely related to the “custard apple.” From this plant he extracted two acetogenins with anticancer prospects. In tests conducted by a major pharmaceutical company, one of those acetogenins — bullatacin — proved 1 million times more potent than the common anticancer drug cisplatin in inhibiting the growth of human ovarian tumors transplanted into mice. The National Cancer Institute is currently testing his acetogenins in in vitro trials, he says.

The acetogenins’ mode of action differs from that of most anticancer drugs: Rather than killing a cell by scrambling its DNA, they starve the rapidly divinding cells of the ATP that fuels them. As a result, McLaughlin says, “I don’t think we’ll have to worry about these [acetogenins] ever causing cancer–as some anticancer agents do.”

“Nor do we have to rely on Cuba to get bullatacin, the most potent acetogenin,” McLaughlin notes. In the March JOURNAL OF NATURAL PRODUCTS, he and his co-workers will announce isolating bullatacin and six other biologically active acetogenins–including a new compound, trilobacin–from the common pawpaw. The report also shows that trilobacin exhibited high levels of growth suppression in cultured cells of some leukemias, small-cell lung cancer, colon cancer, melanoma, ovarian cancer and renal cancer.

If the pawpaw contains so many potentially toxic agents, how can anyone stomach its fruit? In moderation, McLaughlin observes, the ripe fruit can prove quite edible. But his team’s assays indicate that unripe fruits “are almost as toxic as the twigs — really potent.” And that makes sense, he suspects, “because nature wanted to discourage animals from eating it and spreading its seeds before the fruit was ripe.”

Source:  Paw Paw Research.com

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Graviola & Paw Paw For Treating Cancer

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by R. Webster Kehr

How It Works

North American Paw Paw Tree

North American Paw Paw Tree

These products come from trees in the tropical areas of South and North America. They kill cancer cells as a minimum, but may have other affects on cancer. Paw Paw is known to work by blocking ATP production and thus reduce the voltage of the cancer cell to the point it falls apart (apoptosis or programmed cell death). Because Paw Paw and graviola are cousins, I assume that is also the way graviola works. They are also known to build the immunity system.

 

Graviola Tree and Paw Paw Tree

This is one of those treatments for cancer that is fairly new, meaning it has only recently found its way onto the internet. Nevertheless, there have been a lot of scientific studies on these two products. At the current time most of the articles for Graviola and cancer come from a single source – the Health Sciences Institute (see the links below), though there are a growing number of independent articles.

I recommend graviola on the basis of several scientific articles, several testimonials, and several comments by practitioners (mostly from Brazil), however, Paw Paw is actually stronger than graviola at treating cancer. Paw Paw is the more potent of the two because of its more sophisticated and larger molecular structures. Graviola is sometimes called “Brazilian Paw Paw,” which can cause some confusion.

Paw Paw is clearly more powerful than graviola when treating cancer, if the quality of the processing is comparable. However, I would take freshly cut graviola over bottled Paw Paw (but American’s can’t get freshly cut graviola). Graviola only has single ring compounds, while the Paw Paw’s acetogenins have several double ring compounds (e.g. bullatacin) which makes Paw Paw much more powerful.

Paw Paw works (and I assume graviola as well) by slowing down or stopping the production of ATP. This in turn lowers the voltage of the cell. For normal cells, there is plenty of ATP, thus lowering the level of ATP has no effect on the cell. However, with cancer cells, due to the way they create energy (by fermentation), ATP is far more critical.

When the ATP level, and the energy of the cell level, drops to a critical level the cell falls apart. The residual pieces of the dead cancer cell are called “lysing” and I assume are similiar to other apoptosis (programmed cell death) killed cells. If that is the case, then part of the lysing is literally “eaten” by other cells (called: phagocytosed).

However, because the cancer cells in a cancer patient are frequently clusted together, a large amount of lysing can be created within a cancer patient such that high levels of clustered lysing cannot be eaten by surrounding cells. Such a situation is especially dangerous for lung cancer patients and brain cancer patients where a clustered amount of lysing can be very dangerous.

Here is some technical information on graviola:

 

  • “The Annonaceous acetogenins discovered in graviola thus far include: annocatalin, annohexocin, annomonicin, annomontacin, annomuricatin A & B, annomuricin A thru E, annomutacin, annonacin, annonacinone, annopentocin A thru C, cis-annonacin, cis-corossolone, cohibin A thru D, corepoxylone, coronin, corossolin, corossolone, donhexocin, epomuricenin A & B, gigantetrocin, gigantetrocin A & B, gigantetrocinone, gigantetronenin, goniothalamicin, iso-annonacin, javoricin, montanacin, montecristin, muracin A thru G, muricapentocin, muricatalicin, muricatalin, muri-catenol, muricatetrocin A & B muricatin D, muricatocin A thru C muricin H, muricin I, muricoreacin, murihexocin 3, murihexocin A thru C, murihexol, murisolin, robustocin, rolliniastatin 1 & 2, saba-delin, solamin, uvariamicin I & IV, xylomaticin.
    http://www.naturalpharmacy.com/learn-more/graviola

Graviola, like its cousin Paw Paw, is known to greatly enhace the effectiveness of another alternative cancer treatment – Protocel. However, generally it is recommended that Protocel not be taken with graviola or Paw Paw. There are exceptions, see my Protocel article for more information:
Protocel Article

Because of the similarity of Paw Paw and graviola to Protocel, there is no doubt in my mind that in order to maximize the effectiveness of these products, they should be taken in exactly the same way as Protocel. In other words, every 6 hours, EXACTLY – 24 hours a day.

I would strongly recommend studying the Protocel article linked to above for information that will help you take these products.

Paw Paw has been shown to kill multiple-drug resistant (MDR) cells, which result from someone taking chemotherapy. This is critical to understand because when a person on orthodox treatments comes out of remission into regression, a high percentage of their cancer cells are MDR cells. This would REQUIRE the use of Paw Paw to treat these patients.

Paw Paw is not toxic according to studies with beagles (dogs). It appears to be impossible to ‘overdose’, 32 capsules 4x/day were non toxic because it caused vomiting.

Paw Paw gravitates towards cells that use a lot of energy and then cuts off their energy supply. Since cancer cells use 10-17 times as much energy as a normal cell, Paw Paw acts on cancer cells. It is the same mechanism that made it so useful as a parasite cleanse and to kill hair lice.

It is also the reason that pregnant women should not take Paw Paw. Paw Paw could see some of the fast growing cells in the fetus as high energy cells. In addition, some of the cells in a fetus are very similar to cancer cells (i.e. the “trophoblastic” cells), so pregnant women should ALWAYS be careful what they take for cancer.

If no cancer, parasite, or other high energy users are available, Paw Paw may gravitate towards fast growing cells lining the digestive and intestinal system walls. This is why the main manufacturer, Nature’s Sunshine, strongly cautions against long term use for non-cancer patients. Some people with cancer have reported digestion distress such as nausea. For this reason it is recommended to take Paw Paw with food.

 

Warnings For Both Products

In the past, it was thought that the effectiveness of Paw Paw, like Protocel, was damaged by taking antioxidants with Paw Paw. However, new research has shown that this is not the case. I quote from an email I received:

 

  • “The head of NSP research, Dr. Bill Keller, provided Paw Paw with supporting products to a research oncologist and his laboratory to test with actual cultures. Several of Nature’s Sunshine strong antioxidants were also provided. The research personnel concluded overwhelmingly that there was no negative prevention of Paw Paw action as a result of the antioxidants.”
    email to CancerTutor

Important Note: The above email is not the end of the story. Nature’s Sunshine researchers are still looking into this issue because there are some antioxidants that DO increase ATP energy, which would conflict with the use of Paw Paw, graviola and Protocel. I will put the results of their research on this web site as soon as I get more information!!

Also, I do not know which antioxidants may conflict with graviola. If you buy graviola, check with the vendor for recommendations.

No one with Parkinsons Disease should take Paw Paw or graviola unless alkaloid-free preparations are used. There is also a possibility of allergic reactions in sensitive individuals.

 

Supercharging This Treatment

Paw Paw is generally considered stronger than graviola. This does not mean that graviola should not be used. Cat’s Claw and Ellagic Acid seem to be items that people like to combine with Graviola. However, if you take Cat’s Claw make sure you take a product like Samento, which is a TOA-free Cat’s Claw.

Source:  Cancer Tutor

Written by Tracey

November 18, 2008 at 5:44 am

Paw Paw & Cancer: From Discovery to Clinical Trials

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Mom, here is a YouTube video series about Paw Paw and cancer presented by Dr. Jerry McLaughlin – a professor from Perdue University. It’s a good series of videos. I’ve put them in order so you can just go down the list.

Paw Paw & Cancer: From Discovery to Clinical Trials – Part 1

Paw Paw & Cancer: From Discovery to Clinical Trials – Part 2

Paw Paw & Cancer: From Discovery to Clinical Trials – Part 3

Paw Paw & Cancer: From Discovery to Clinical Trials – Part 4

Paw Paw & Cancer: From Discovery to Clinical Trials – Part 5

Paw Paw & Cancer: From Discovery to Clinical Trials – Part 6

Paw Paw & Cancer: From Discovery to Clinical Trials – Part 7

Paw Paw & Cancer: From Discovery to Clinical Trials – Part 8

Paw Paw & Cancer: From Discovery to Clinical Trials – Part 9

Here’s a link to Dr. McLaughlin’s formulation of Paw Paw at Nature’s Sunshine:

Paw Paw Cell-Reg (120)

Written by Tracey

October 10, 2008 at 9:26 pm