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Archive for the ‘Curcumin (Turmeric)’ Category

The Benefits of Curcumin

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Mom,

Below are a series of videos I found on YouTube regarding Curcumin (a chemical found in the spice, Turmeric). It has shown wonderful healing benefits for arthritis for a long time, but researchers are now finding it works well on cancer too. In fact, there isn’t a type of cancer that hasn’t responded to curcumin when combined with bioperine (a compound in simple black pepper). I guess the bioperine in black pepper aids significantly in the absorption of the curcumin. However, you’ll want to ask your doctor if it’s okay to take it because the bioperine will cause anything else you’re taking to have increased absorption, as well.

Love ya,

Tracey
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Written by Tracey

September 30, 2008 at 3:33 am

A Report on Curcumin’s Anti-Cancer Effects

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Ground Tumeric Root

Ground Turmeric Root

Imagine a natural substance so smart it can tell the difference between a cancer cell and a normal cell; so powerful it can stop chemicals in their tracks; and so strong it can enable DNA to walk away from lethal doses of radiation virtually unscathed. Curcumin has powers against cancer so beneficial that drug companies are rushing to make drug versions. Curcumin is all this and more.

Curcuma longa is a ginger-like plant that grows in tropical regions. The roots contain a bright yellow substance (turmeric) that contains curcumin and other curcuminoids. Turmeric has been used in Ayurvedic and Chinese medicine for centuries. But it’s only within the past few years that the extraordinary actions of curcumin against cancer have been scientifically documented. Among its many benefits, curcumin has at least a dozen separate ways of interfering with cancer.

Curcumin Blocks Estogen Mimicking Chemicals

One of the things that sets curcumin apart from most other anti-cancer supplements (I3C being an exception), is that this phenolic can actually block chemicals from getting inside cells. Importantly, curcumin can interfere with pesticides that mimic estrogen. These include DDT and dioxin, two extremely toxic chemicals that contaminate America’s water and food. (Dioxin is so toxic that a few ounces of it could wipe out the entire population of New York City). Curcumin has the unique ability to fit through a cellular doorway known as the aryl hydrocarbon receptor. This is a feat it shares with estrogen and estrogen-mimicking chemicals. Because it can compete for the same doorway, curcumin has the power to block access to the cell and protect against estrogen mimickers.

Like estrogen, estrogen-mimicking chemicals promote the growth of breast cancer. In a study on human breast cancer cells, curcumin reversed growth caused by 17b-estradiol by 98%. DDT’s growth-enhancing effects on breast cancer were blocked about 75% by curcumin.

Two other estrogen mimickers were tested for their ability to enhance breast cancer. Chlordane and endosulfane together make breast cancer cells grow about as much as17b-estradiol. Curcumin can reverse that growth about 90%. Adding the soy phytochemical, genistein, causes a 100% growth arrest.

Curcumin’s ability to block other chemicals have been documented. It has been tested against paraquat (weed killer), nitrosamines (in cooked meat and “lunch” meats) and carbon tetrachloride (a solvent in varnish and other products). In all cases, curcumin is able to block the chemical’s effect. The beneficial effects are evident in a study where mice were treated with diethylnitrosamine. All mice treated with this chemical would usually develop liver cancer. However, when treated with curcumin, the percentage of animals developing cancer went from 100% to 38%, and the number of tumors dropped by 81%.

Drug companies rush to make synthetic versions

One of the hottest areas of oncology drug development is in the area of kinase inhibitors. Kinases are the equivalent of phone lines into cancer cells. There are over 2000 known protein kinases, or phone lines. These lines run from the outside of a cell into the DNA command center. They carry messages. Cut these lines, and you can effectively stop the growth of some types of cancer cells.

Curcumin effectively blocks some of the lines. In cells treated with curcumin, certain “grow” signals are blocked from reaching the cell.

The most well-studied growth factor blocked by curcumin is nuclear factor-k B. NF-kB is activated by chemical messengers known as cytokines. Cytokines help the immune system, but they also activate signals that tell cells to multiply, grow. By interfering with those signals, curcumin effectively stops the growth of cancer cells by kinase pathways. It has been demonstrated, for example, that curcumin can prevent the bug that causes ulcers (Helicobacter pylori) from causing cancer. H. pylori increases levels of a cytokine (IL-8) that activates NF-kB. Curcumin blocks the process.

Drug companies are rushing to patent chemicals that do what curcumin does-inhibit kinases. AstraZeneca has gotten one off the ground called “Iressa”. Iressa inhibits protein kinase C (PKC), a kinase that plays a significant role in cancer. PKC transmits signals from the “epidermal growth factor (EGF) receptor.” Cutting off signal transmission through EGF significantly slows the growth of any cancer that uses this factor to grow-glioma, breast, prostate, skin and lung cancers.

Curcumin has long been known for its ability to prevent skin cancer. In 1993, researchers in Taiwan reported that curcumin inhibits PKC. The next year it was reported that curcumin blocks EGF signals up to 90% and stops growth.

It turns out that the structure of curcumin enables it to inhibit multiple kinases. This ability is shared with other phytochemicals including silymarin, apigenin and hypericin. While drug companies rush to try to recreate safe, patentable, chemical versions of this structure, curcumin sits ready and available for use. Blocking kinases, however, is only one of curcumin’s anti-cancer effects.

Inflammation: Curcumin suppresses LOX and COX

Squamous cell carcinoma can affect the bronchial tubes, mouth or skin. When researchers at the University of Missouri treated oral squamous cell carcinoma cells with curcumin, it caused significant growth inhibition.

Curcumin is also notably effective against colon cancer. Inflammation appears to play a significant role in promoting this type of cancer. Curcumin has long been known for its anti-inflammatory action. More recently, it has been shown that curcumin inhibits cyclooxygenase (COX) and lipoxygenase (LOX), two enzymes that promote inflammation. Inflammation is in the limelight these days because of the discovery that people who take nonsteroidal anti-inflammatory drugs (NSAIDs), including aspirin, have stunning protection against colon cancer. Inflammation, it turns out, plays significant and diverse roles in the initiation and promotion of cancer. Oxidative stress helps activate PKC, for example. Part of curcumin’s ability to block PKC signals is due to its powerful antioxidant activity.

Curcumin possesses several other anti-cancer benefits that make it useful for cancer prevention. One of its most recognized features is its antioxidant action. Turmeric is a spice that contains curcumin. It has traditionally been used as a food preservative for a good reason: it keeps food from going rancid-oxidizing. And just as it keeps oxygen from turning meat rancid, it protects our own bodies from damaging free radicals. Free radicals promote cancer by damaging DNA and activating genes.

Radiation damages DNA partially through free radicals. In a recent study, it was demonstrated that under laboratory conditions, curcumin could protect bacteria from a lethal dose of radiation almost perfectly. Bacterial DNA emerged virtually intact.

Curcumin kills cancer cells

Curcumin can stop cancer in its earliest stages, long before it’s detectable. It works at the level of the cell. One of the things it does is to tell damaged cells to self-destruct so they won’t keep multiplying. The process is called “apoptosis” and it’s the body’s way of destroying abnormal cells that can become cancerous. Cancer cells can circumvent the process, but curcumin can override them and send “self-destruct” signals to many different types of cancer cells. Curcumin does not induce apoptosis of healthy cells, only cancerous ones. It identifies cancer cells by their abnormal chemistry. Unfortunately, it doesn’t work in all types of cancer, but Indian researchers may have figured out why. Their findings, published in the Journal of Biological Chemistry, may lead to ways of making most types of cancer susceptible to curcumin’s effects.

Before apoptosis is induced, curcumin stops cancer cells from multiplying. In cancer research, this is known as “interrupting the cell cycle.” The cell cycle can be interrupted at several different points. This is the rationale behind using various chemotherapy treatments in one person. One drug stops the cells when they are in one stage of growth; another stops them at another stage. Using a variety of drugs that stop growth at different stages increases the chances of killing all the cancer cells. Curcumin arrests the growth of cancer cells in the G2 stage.

Other phytochemicals stop the cell cycle at other stages. Genistein, a soy phytochemical, arrests growth at G2, like curcumin. But epigallocatechin-3-gallate (EGCG) from green tea, arrests cancer cell growth at the G1 phase. Combining EGCG with curcumin increases the odds of killing more cells. Researchers at Sloan-Kettering Cancer Center have suggested that EGCG and curcumin be used together for cancer prevention.

Curcumin enhances immunity

Curcumin can also help the body fight off cancer should some cells escape apoptosis. When researchers looked at the lining of the intestine after ingestion of curcumin, they found that CD4+ T-helper and B type immune cells were greater in number. In addition to this localized immune stimulation, curcumin also enhances immunity in general. Researchers in India have documented increased antibodies and more immune action in mice given curcumin.

Curcumin stops angiogenesis

All of the above actions of curcumin stop cancer before it has a chance to become detectable. If cancer grows to the point that it is a detectable tumor, curcumin can still have an effect.

Certain enzymes enable tumors to create a blood supply for themselves. Known as “angiogenesis,” this phenomenon allows tumors to invade surrounding tissue and spread. Working with blood vessels of the eye (where angiogenesis creates big problems for vision), researchers at Tufts University were able to inhibit blood vessel formation by using curcuminoids. Curcumin blocks AP-1, which enhances angiogenesis.

Curcumin may also inhibit angiogenesis by chelating metals used by enzymes that promote the growth of blood vessels. Some of the enzymes that promote angiogenesis are known as “metalloproteinases.” Metalloproteinases require metals to work. Curcumin chelates iron and probably copper-both of which help metalloproteinases create new blood vessels for tumors. In a study on a highly invasive form of human liver cancer, curcumin inhibited metastasis 70% by suppressing metalloproteinase-9. Curcumin appears to be very protective against liver cancer. In a more recent study, the incidence of liver cancer was slashed 62%, with the number of tumors decreasing by 81% in mice given curcumin four days before a carcinogenic chemical.

The cancer preventive effects of curcumin are powerful and proven. Curcumin interferes with the ability of estrogen-mimicking and other chemicals to do damage (a trait it shares with I3C). It is a powerful antioxidant that can alter gene expression, stop the cell cycle, and induce the self-destruction of cancer cells without affecting healthy ones. By blocking signals known as kinases, curcumin interrupts signals that enable cancer cells to grow. In addition, curcumin enhances immunity and blocks the invasion and metastases of tumors. Curcumin significantly reduces the risk of cancer after chemical exposure, and appears especially beneficial against colon and liver cancers. The actions of curcumin have been the subject of presentations at major meetings on cancer research, and the object of study by researchers at the most prestigious universities in the world. If curcumin were a drug, it would be hailed as one of the best all-around cancer drugs ever invented. As it is, it’s a phytochemical with impeccable credentials, thousands of years of use behind it, and a very small price tag. No wonder a host of drug companies want to imitate it.

Note: There is still not a scientific consensus on how those with active cancer may best take advantage of the multiple potential benefits of curcumin. Most cancer patients have been taking 1800 to 3600 mg a day of curcumin. Life Extension has recommended that curcumin not be combined with the chemotherapy drug Camptosar (irinotecan) because of one animal study that indicated a possible adverse effect. Since curcumin has not been adequately tested with other chemotherapy drugs, it might be safe to wait until chemotherapy is completed before initiating curcumin. Cancer patients using curcumin may want to avoid high doses of “thiol” nutrients such as cysteine, lipoic acid, SAMe and glutathione because these nutrients might interfere with curcumin’s PKC inhibiting effects in actively growing cancer. Since thiol compounds are critically important anti-aging nutrients, cancer patients may consider avoiding or reducing thiol nutrients for a three to six month period while consuming high doses of curcumin (along with soy, green tea extracts, I3C and other nutrients that have shown specific anti-cancer effects). A comprehensive report on suggested nutrient dosing schedules for cancer patients will be published in a future edition of this magazine.

Source:  Life Extension Magazine

 

Written by Tracey

September 30, 2008 at 2:55 am

Curcumin & Bioperine: Cancer Treatment and Prevention

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Turmeric Spice

Turmeric Spice

 

Is there a curcumin cancer cure? Could curcumin prevent cancer? Is there a role for curcumin and turmeric in cancer control?

Curcumin, the pigment that makes the curry spice turmeric a bright orange-yellow, is one of the best-researched potential preventatives for a number of kinds of cancer.

Turmeric is a member of the ginger family.

On a molecular level, curcumin interacts with an extraordinary range of cellular processes involved in cancer. Curcumin:

  • Stops the activation of some”transcription factors” that lay down the DNA for a new cancer cell,
  • Acts in the same as other anti-inflammatory agents in stopping the expression of growth factors in existing cancer cells,
  • And (in almost all kinds of cancer) activates a “watchdog” gene, p53, that deactivates cells that have become cancerous.

Curcumin is non-toxic even if it is taken in doses 30-40 times more than needed for it to work, up to 12 grams (12,000 mg) a day. The body uses curcumin in various antioxidant processes that it does not build up in the bloodstream in most people even when taken in doses of 10,000 to 12,000 mg a day.

And there’s no reason to try to build up a bloodstream concentration of curcumin if you get just a little more than once a day. The liver clears curcumin out of circulation in 8 to 12 hours.

What is the evidence that curcumin might prevent cancer? Well, aside from the over-100 studies of curcumin in the laboratory, curcumin has been used in clinical trials.

In a study of 62 patients who had various skin cancers and pre-cancers (actinic keratosis, basal cell carcinoma that had not infiltrated below the skin, and external genital warts), researchers found that a curcumin ointment applied to the skin brought lasting relief from the itching, burning, and ache associated with the cancer and stopped cancer growth.

Curcumin stopped skin itching in all the patients, “dried up” oozing lesions in 70 per cent of cases, and actually reduced the size of the cancer in 10 per cent of patients. Only one patient had any adverse reaction to curcumin, an allergy. The ointment consisted of 1 per cent curcumin in a cream base.

Curcumin has also been treated in other pre-cancerous conditions, including:

  • Bladder cancer,
  • Bowen’s disease of the skin (squamous cell carcinoma),
  • Leukoplakia (white patches inside the mouth found in smokers),
  • Intestinal metaplasia of the stomach (a kind of pre-cancer of the stomach caused by Helicobacter pylori infection and associated with peptic ulcer disease).

In 10 out of 12 cases in this very small trial, pre-cancer patients who used up to 12,000 mg of curcumin a day did not go on to develop cancer. Moreover, in one patient with bladder cancer, two with leukoplakia, one with a cervical tumor, and two with squamous cell carcinoma, the pre-cancerous lesions actually shrank.

Curcumin (in a dosage of 3,600 mg per day) may be beneficial to people who have advanced drug-resistant colorectal cancer. Scientists at least know that curcumin concentrates in the cancer tissues of the colon and that some markers of cancer activity drop significantly after the patient takes curcumin for four months.

Finally, in otherwise untreatable advanced pancreatic cancer, a daily dose of 8,000 mg of curcumin has been tried for up to two months. Two months, as you may know, is a very long time to be treating advanced pancreatic cancer.

That’s what science knows about curcumin and cancer in humans. Dozens of other studies are in the works, however, for treatment of esophageal cancers, stomach cancers, liver cancer, lung cancers, lymphoma, and breast cancer. And doctors are following up on an intriguing observation that women who live in countries where turmeric-based (and curcumin-loaded) curries are part of the daily diet have very low rates of breast cancer.

Curcumin does not interfere with any other therapy you should continue if you have or if your doctor believes you may develop cancer. Its side effects are very rare, and it’s cheap. There’s no way to prove that curcumin could prevent cancer for you, but it should rank very high on your list of natural preventive measures that may help keep you healthy.

CURCUMIN & BIOPERINE

If you buy a curcumin supplement in North America, chances are it will be formulated with an additive called bioperine.

This well-publicized addition to nutritional supplements is a chemical extract from black pepper. Ayurvedic medicine adds black pepper to countless herbal formulas not for any particular benefit in itself, but to help the body absorb the active principles of other herbs. This black pepper chemical concentrates the ability of “black pepper” to concentrate the absorption of other plant chemicals. The makers of hundreds of different supplements include this chemical to help the body absorb one active ingredient or another from a standardized herbal or natural product.

Bioperine makes curcumin better absorbed, too. A clinical trial sponsored by the Sabinsa Corporation (which manufactures the ingredient for nutritional product makers around the world) found that adding their ingredient to curcumin in supplements:

 

  • Increases the maximum bloodstream concentration by almost 50 per cent,
  • Increases the half-life (time for half the supplement in circulation to be broken down by the liver) by almost 50 per cent, but more importantly,
  • Provides nearly 20 times as much of the active ingredient to cells before the curcumin is removed from the bloodstream by normal hepatic processes.

 

Studies at Sabinsa found similar effects when the reagent was combined with selenium, vitamin B6, beta-carotene, or vitamin C.

That’s the good side of bioperine. There’s one consideration for users of supplements that include this compound. It does increase absorption of nutrients, but there are also a few prescription medications that it can also make more bioavailable:

 

  • Phenytoin (Dilantin) for seizure disorders,
  • Propanolol (Inderal) for high blood pressure and muscle control, and
  • Theophylline (Theo-Dur) for asthma.

 

If you take any of these medications, be aware that bioperine makes them absorbed more completely and eliminated more quickly. It will increase their effects, both good and bad.

Source:  Savvy Natural Healer

 

Written by Tracey

September 30, 2008 at 2:31 am